Endocrine Abstracts

An association of the single nucleotide polymorphism (SNP) in the promoter gene that codify for 17b-HSD5 enzyme (71A>G) with polycystic ovary syndrome (PCOS) has been suggested in previous studies. Given the role of 17b-HSD5 in androgenic metabolism producing testosterone from precursors, the aim of this study was to assess whether non-obese PCOS women with the variant allele G have different response on hirsutism and on hormonal and metabolic variables to oral contracepti...